Computational RNA Epigenetics
نویسندگان
چکیده
منابع مشابه
Computational epigenetics
Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression. Patterns of epigenetic information are faithfully propagated over multiple cell divisions, which makes epigenetic regulati...
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Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression. Patterns of epigenetic information are faithfully propagated over multiple cell divisions, which makes epigenetic regulati...
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Several recent landmark papers describing N(6) -methyladenosine (m(6) A) RNA modifications have provided valuable new insights as to the importance of m(6) A in the RNA transcriptome and in furthering the understanding of RNA epigenetics. One endogenous enzyme responsible for demethylating RNA m(6) A, FTO, is highly expressed in the CNS and is likely involved in mRNA metabolism, splicing or oth...
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Epigenetics has recently emerged as a critical field for studying how non-gene factors can influence the traits and functions of an organism. At the core of this new wave of research is the use of computational tools that play critical roles not only in directing the selection of key experiments, but also in formulating new testable hypotheses through detailed analysis of complex genomic inform...
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Lesley J. Collins1, Barbara Schönfeld2,3, and Xiaowei Sylvia Chen4 1Massey Genome Service, Massey University, Palmerston North, New Zealand 2Allan Wilson Centre for Molecular Ecology and Evolution, Massey University, Palmerston North, New Zealand 3Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand 4Department of Biochemistry, University of Otago, Dunedin 9054, ...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2020
ISSN: 1389-2029
DOI: 10.2174/138920292101200305145123